It really depends where you currently are in terms of stats, cash, and what you consider "high". You definitely don't want to start looking at using Stat Enhancers yet, stick with a 3x Xanax + Refill daily routine. This is your training routine for a long long time. Build up your networth so you can afford to invest and build up more of these basic training supplies so that eventually you won't need to worry about them.
Here's a few more threads on this topic that might be useful.
You have played this game for over 12 years, so your stats should be well in the billions simply by taking xanax and training your energy in the gym. There is no special tricks to it, just train a lot. Stats Enhancers will not become feasible until you are in the billions with the individual stat you are going to train it with.
Using FHCs, Xanax, Energy Refill I went from 300k to 50 mill in roughly 2 months. Once you hit 50 mill, your gains are no longer exponential and are fixed. After that just keep on the same grind until 2B.
People tend to say that SEs are worth it depending on your income, when the stat you are boosting is 1.5b-2b. It takes roughly 70 SEs to double your stats.